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Mipsagargin

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Drug Profile

Mipsagargin

Alternative Names: G-202; Thapsigargin prodrug

Latest Information Update: 03 Aug 2022

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At a glance

  • Originator Johns Hopkins University
  • Developer National Cancer Institute (USA); Rebus Holdings; University of Texas Health Science Center at Houston
  • Class Antineoplastics; Drug conjugates; Lactones; Peptides; Sesquiterpenes
  • Mechanism of Action Sarcoplasmic reticulum calcium-transporting ATPase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Liver cancer
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Discontinued Cancer; Gastric cancer; Glioblastoma; Liver cancer; Prostate cancer; Renal cell carcinoma; Solid tumours

Most Recent Events

  • 31 Dec 2021 Discontinued - Phase-I for Solid tumours (Late-stage disease) in USA (IV)
  • 31 Dec 2021 Discontinued - Phase-II for Glioblastoma (Recurrent, Second-line therapy or greater) in USA (IV)
  • 31 Dec 2021 Discontinued - Phase-II for Liver cancer (Late-stage disease, Second-line therapy or greater) in USA (IV)

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