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Drug Profile


Alternative Names: G-038390; G-038390.1; GDC-0980; GDC-0980.1; RG-7422

Latest Information Update: 04 Nov 2018

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At a glance

  • Originator Genentech; Piramed
  • Developer Genentech
  • Class Antineoplastics; Heterocyclic bicyclo compounds; Morpholines; Piperazines; Pyrimidines; Small molecules
  • Mechanism of Action 1 Phosphatidylinositol 3 kinase inhibitors; MTOR protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued Breast cancer; Endometrial cancer; Non-Hodgkin's lymphoma; Prostate cancer; Renal cancer; Solid tumours

Most Recent Events

  • 24 Jun 2018 Biomarkers information updated
  • 01 Apr 2016 Genentech completes a phase II trial in Breast cancer (Combination therapy, Second-line therapy or greater) in USA, Argentina, Australia, Belgium, Canada, Chile, Czech Republic, Denmark, France, Germany, Hong Kong, Israel, Italy, South Korea, Malaysia, Mexico, New Zealand, Peru, Russia, Singapore, Spain, Thailand and the UK (NCT01437566)
  • 01 Jun 2015 Genentech completes a phase II trial in Renal cancer (Metastatic disease, Second-line therapy or greater) in USA, France, United Kingdom, Germany and Spain (NCT01442090)
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