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Fexagratinib - Abbisko Therapeutics

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Drug Profile

Fexagratinib - Abbisko Therapeutics

Alternative Names: ABSK-091; AZD-4547

Latest Information Update: 28 Feb 2024

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At a glance

  • Originator AstraZeneca
  • Developer Abbisko Therapeutics; AstraZeneca; Dust Diseases Authority; Institute of Respiratory Health; National Cancer Institute (USA); University of Glasgow; University of Leeds; University of Wisconsin-Madison
  • Class Antineoplastics; Benzamides; Phenyl ethers; Piperazines; Pyrazoles; Small molecules
  • Mechanism of Action Type 1 fibroblast growth factor receptor antagonists; Type 3 fibroblast growth factor receptor antagonists; Type-2 fibroblast growth factor receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Gastric cancer; Lymphoma; Multiple myeloma; Solid tumours; Urogenital cancer
  • Preclinical Skin cancer
  • No development reported Liver cancer
  • Discontinued Bladder cancer; Breast cancer; Glioblastoma; Head and neck cancer; Lung cancer; Mesothelioma; Non-small cell lung cancer; Oesophageal cancer

Most Recent Events

  • 28 Feb 2024 No recent reports of development identified for preclinical development in Liver-cancer in China (PO)
  • 23 Jan 2024 Preclinical trials in Solid tumours (Monotherapy) in China (PO) (Abbisko Therapeutics pipeline, January 2024)
  • 26 Oct 2022 Pharmacodynamics data from a preclinical studies in Cancer presented at the 34th EORTC-NCI-AACR Symposium on molecular targets and cancer therapeutics (EORTC-NCI-AACR-2022)
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