Drug Profile

Naldemedine - Shionogi

Alternative Names: Naldemedine Tosilate; Rizmoic; S-297995; Symproic

Latest Information Update: 10 Jun 2025

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At a glance

Originator Shionogi
Developer Purdue Pharma; Shionogi
Class Antiemetics; Laxatives; Small molecules
Mechanism of Action Opioid mu receptor antagonists

Orphan Drug Status

Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

No
New Molecular Entity Yes
Available For Licensing Yes

Highest Development Phases

Marketed Constipation
Discontinued Postoperative ileus

Most Recent Events

30 May 2025 Preregistration for Constipation in China (PO)
04 Oct 2022 Discontinued - Phase-II for Postoperative ileus (In the elderly, In adults) in USA (PO)
22 Mar 2022 BioDelivery Sciences International has been acquired by Collegium Pharmaceutical

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