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Ornithine phenylacetate - Ocera Therapeutics

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Drug Profile

Ornithine phenylacetate - Ocera Therapeutics

Alternative Names: L-Ornithine phenylacetate; MNK 6106; MNK-6105; OCR-002; OP; Ornithine hydrochloride/sodium phenylacetate; Sodium phenylacetate/ornithine hydrochloride; UCL-L1V

Latest Information Update: 30 Sep 2021

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At a glance

  • Originator University College London
  • Developer Ocera Therapeutics
  • Class Basic amino acids; Diamino amino acids; Esters; Hepatoprotectants; Neuroprotectants; Phenylacetates; Small molecules
  • Mechanism of Action Aminohydrolase modulators; Ammonia scavengers; NF-kappa B modulators; Nitric oxide synthase modulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Hepatic encephalopathy; Liver failure
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase II/III Hepatic encephalopathy
  • Phase II Liver cirrhosis; Liver failure
  • No development reported Non-alcoholic fatty liver disease

Most Recent Events

  • 22 Sep 2021 Mallinckrodt withdraws a phase III trial, prior to enrolment, for Hepatic-encephalopathy (IV, Infusion) (NCT04128462)
  • 28 May 2021 No recent reports of development identified for preclinical development in Non-alcoholic-fatty-liver-disease in USA (IV, Infusion)
  • 28 May 2021 Mallinckrodt plans a phase III trial for Hepatic-encephalopathy (IV) in first half of 2022 in USA

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