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At a glance
Originator
University College London
Developer
Ocera Therapeutics
Class
Basic amino acids; Diamino amino acids; Esters; Hepatoprotectants; Neuroprotectants; Phenylacetates; Small molecules
Mechanism of Action
Aminohydrolase modulators; Ammonia scavengers; NF-kappa B modulators; Nitric oxide synthase modulators
Orphan Drug Status
Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.
Yes
-
Hepatic encephalopathy; Liver failure
New Molecular Entity
Yes
Available For Licensing
Yes
Highest Development Phases
Phase II/III
Hepatic encephalopathy
Phase II
Liver cirrhosis; Liver failure
Preclinical
Non-alcoholic fatty liver disease
Most Recent Events
30 Oct 2019
Mallinckrodt plans a phase III trial for Hepatic-encephalopathy in November 2019 (NCT04128462) (EudraCT2019-001635-31)
28 Oct 2019
No recent reports of development identified for phase-I development in Hepatic-encephalopathy(Prevention) in USA (IV, Infusion)
01 Dec 2018
Phase-II clinical trials in Liver cirrhosis in USA (PO) (NCT03712280)
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