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Epetraborole - Pfizer

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Drug Profile

Epetraborole - Pfizer

Alternative Names: AN-3365; AN2-501971; BRII-658; GSK '052; GSK-052; GSK-2251052

Latest Information Update: 19 Nov 2024

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At a glance

  • Originator Anacor Pharmaceuticals
  • Developer AN2 Therapeutics; Anacor Pharmaceuticals; GlaxoSmithKline
  • Class 2 ring heterocyclic compounds; Anti-infectives; Antibacterials; Benzene derivatives; Organic boron compounds; Small molecules
  • Mechanism of Action Leucyl-tRNA synthetase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Nontuberculous mycobacterium infections
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II/III Nontuberculous mycobacterium infections
  • Phase I Melioidosis
  • Suspended Gram-negative infections
  • Discontinued Intra-abdominal infections; Urinary tract infections

Most Recent Events

  • 13 Nov 2024 AN2 Therapeutics plans an End-of-Phase 2 meeting with FDA in the first half of 2025
  • 13 Nov 2024 Interim adverse events and efficacy data from a phase-II/III trial in Nontuberculous mycobacterium infections released by AN2 Therapeutics ,
  • 13 Nov 2024 AN2 Therapeutics plans a phase-II proof-of-concept trial for Melioidosis in second half of 2025

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