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Epetraborole - Pfizer

Drug Profile

Epetraborole - Pfizer

Alternative Names: (S)-3-aminomethylbenzoxaborole; ABX; AN-3365; GSK '052; GSK-052; GSK-2251052

Latest Information Update: 26 Mar 2013

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At a glance

  • Originator Anacor Pharmaceuticals
  • Developer Anacor Pharmaceuticals; GlaxoSmithKline
  • Class 2 ring heterocyclic compounds; Antibacterials; Benzene derivatives; Organic boron compounds; Small molecules
  • Mechanism of Action Leucyl-tRNA synthetase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Suspended Gram-negative infections
  • Discontinued Intra-abdominal infections; Urinary tract infections

Most Recent Events

  • 21 Mar 2013 AN 3365 is no longer licensed to GlaxoSmithKline. Anacor is considering its options for further development of the compound, if any
  • 21 Mar 2013 Suspended - Phase-II for Gram-negative infections in USA (IV)
  • 05 Oct 2012 Discontinued - Phase-I for Gram-negative infections in Australia (IV)
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