Tepotinib - Merck KGaA

Drug Profile

Tepotinib - Merck KGaA

Alternative Names: EMD-1214063; MSC-2156119; MSC-2156119J

Latest Information Update: 13 Apr 2018

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At a glance

  • Originator EMD Serono; Merck KGaA; Merck Serono
  • Class Antineoplastics; Nitriles; Piperidines; Pyridazines; Pyrimidines; Small molecules
  • Mechanism of Action Proto oncogene protein c met inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Adenocarcinoma; Hepatocellular carcinoma; Non-small cell lung cancer
  • Phase I Solid tumours

Most Recent Events

  • 12 Apr 2018 Merck plans a phase I trial (Combination therapy, Monotherapy, In volunteers) in Germany (PO) in May 2018 (NCT03492437) (EudraCT2017-004074-34)
  • 29 Mar 2018 Phase I development for Solid tumours (Second-line therapy or greater) is ongoing in USA and Japan (PO, Capsule) (NCT01014936)
  • 27 Mar 2018 Tepotinib receives SAKIGAKE 'fast-track' designation for Non-small cell lung cancer (harboring MET exon 14 skipping mutations) in Japan
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