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Tepotinib - Merck

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Drug Profile

Tepotinib - Merck

Alternative Names: EMD-1214063; MSC-2156119; MSC-2156119J; TEPMETKO

Latest Information Update: 23 Feb 2024

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At a glance

  • Originator EMD Serono; Merck KGaA
  • Class Antineoplastics; Benzonitrile; Piperidines; Pyridazines; Pyrimidines; Small molecules
  • Mechanism of Action Proto-oncogene protein c-met inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Non-small cell lung cancer
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Non-small cell lung cancer
  • Phase II Colorectal cancer; Liver cancer
  • Discontinued Solid tumours

Most Recent Events

  • 15 Feb 2024 US FDA grants traditional approval of Tepotinib for Non-small cell lung cancer
  • 20 Oct 2023 Efficacy data from a phase II VISION trial in Non-small cell lung cancer presented at 48th European Society for Medical Oncology Congress (ESMO-2023)
  • 20 Oct 2023 Pooled analysis of adverse events data from a phase I/II INSIGHT and phase II INSIGHT 2 trial in Non-small cell lung cancer presented at the 48th European Society for Medical Oncology Congress (ESMO-2023)

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