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Research programme: human histone methyltransferase inhibitors - Epizyme/GlaxoSmithKline

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Drug Profile

Research programme: human histone methyltransferase inhibitors - Epizyme/GlaxoSmithKline

Alternative Names: DOT1L inhibitors - Epizyme; HDAC inhibitors - Epizyme; HMT inhibitors - Epizyme; HMT3 inhibitors - Epizyme; WHSC1 inhibitors - Epizyme

Latest Information Update: 22 Aug 2022

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At a glance

  • Originator Epizyme
  • Class Antineoplastics; Small molecules
  • Mechanism of Action DNA methylation inhibitors; Histone deacetylase inhibitors; Histone methyltransferase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • No development reported Acute biphenotypic leukaemia; Cancer; Haematological malignancies; Non-Hodgkin's lymphoma

Most Recent Events

  • 12 Aug 2022 Epizyme has been acquired by Ipsen
  • 31 Dec 2019 Epizyme has patents issued for targeted DOT1L inhibitors in countries worldwide
  • 31 Dec 2017 GlaxoSmithKline terminates its collaboration agreement with Epizyme for human histone methyltransferase inhibitors

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