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Onvansertib - Cardiff Oncology

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Drug Profile

Onvansertib - Cardiff Oncology

Alternative Names: NMS-1286937; NMS-P937; Onvansertib-fumarate; PCM-075; PCM-075H

Latest Information Update: 17 Dec 2025

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At a glance

  • Originator Nerviano Medical Sciences
  • Developer Cardiff Oncology
  • Class Antineoplastics; Piperazines; Pyrazoles; Quinazolines; Small molecules
  • Mechanism of Action Polo-like kinase 1 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Acute myeloid leukaemia
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase II Acute myeloid leukaemia; Colorectal cancer; Pancreatic cancer; Prostate cancer; Small cell lung cancer
  • Phase I/II Triple negative breast cancer
  • Phase I Chronic myelomonocytic leukaemia
  • Preclinical Bladder cancer; Endometrial cancer; Medulloblastoma; Ovarian cancer
  • No development reported Lung cancer; Non-Hodgkin's lymphoma; Solid tumours

Most Recent Events

  • 10 Dec 2025 Efficacy and adverse events data from a phase I trial in Chronic myelomonocytic leukemia released by Cardiff Oncology
  • 10 Nov 2025 Updated efficacy data from a phase II trial in Colorectal cancer released by Cardiff Oncology
  • 30 Jul 2025 Updated efficacy and adverse event data from a phase II trial in Colorectal cancer released by Cardiff Oncology

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