Research programme: proteostasis regulators - Proteostasis Therapeutics

Drug Profile

Research programme: proteostasis regulators - Proteostasis Therapeutics

Alternative Names: PTI-130; PTI-C1811; PTI-P271

Latest Information Update: 30 May 2018

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At a glance

  • Originator Proteostasis Therapeutics
  • Developer Biogen; Cystic Fibrosis Foundation Therapeutics; Harvard Medical School; Proteostasis Therapeutics
  • Class Small molecules
  • Mechanism of Action Alpha-synuclein inhibitors; Cystic fibrosis transmembrane conductance regulator stimulants; Protein folding modulators; Protein modulators; USP14 protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Preclinical Chronic obstructive pulmonary disease; Cystic fibrosis; Neurodegenerative disorders
  • No development reported Inflammation; Metabolic disorders; Parkinson's disease

Most Recent Events

  • 22 Dec 2017 Proteostasis Therapeutics plans a phase I trial for Cystic fibrosis (Combination therapy)
  • 22 Dec 2017 Proteostasis Therapeutics plans dose ranging and proof-of-concept clinical trials for Cystic fibrosis (Combination therapy)
  • 04 Nov 2017 No recent reports of development identified for research development in Inflammation in USA (PO)
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