Birinapant - Medivir AB

Drug Profile

Birinapant - Medivir AB

Alternative Names: SMAC-mimetic; TL-32711

Latest Information Update: 10 Oct 2018

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At a glance

  • Originator Princeton University
  • Developer Medivir AB; National Cancer Institute (USA); University of Pennsylvania
  • Class Amides; Antineoplastics; Indoles; Pyrrolidines; Small molecules
  • Mechanism of Action Apoptosis stimulants; Inhibitor of apoptosis protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Chronic myelomonocytic leukaemia; Colorectal cancer; Myelodysplastic syndromes; Ovarian cancer
  • Phase I/II Acute myeloid leukaemia; Hepatitis B; Precursor cell lymphoblastic leukaemia-lymphoma; Solid tumours
  • No development reported HIV infections; Legionella infections; Lymphoma; Pancreatic cancer; Tuberculosis

Most Recent Events

  • 10 Oct 2018 Interim results from the phase I/II clinical trials in Solid tumours were released by Medivir
  • 28 Jul 2018 No recent reports of development identified for preclinical development in Legionella infections in Australia (IV)
  • 28 Jul 2018 No recent reports of development identified for preclinical development in Tuberculosis in Australia (IV)
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