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Research programme: histone deacetylase-6 protein inhibitors - Karus Therapeutics

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Drug Profile

Research programme: histone deacetylase-6 protein inhibitors - Karus Therapeutics

Alternative Names: HDAC-6 inhibitors - Karus; HDAC6i - Karus; KAR 2581; KAR 3000; KAR 3166

Latest Information Update: 29 Mar 2023

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At a glance

  • Originator Karus Therapeutics
  • Developer Karus Therapeutics; Kings College London; Queen Elizabeth Hospital
  • Class Antineoplastics; Depsipeptides; Small molecules
  • Mechanism of Action HDAC6 protein inhibitors; Histone deacetylase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued Haematological malignancies; Inflammation; Psoriasis; Rheumatoid arthritis; Solid tumours; Transplant rejection

Most Recent Events

  • 31 Mar 2021 Discontinued - Preclinical for Haematological malignancies in United Kingdom (PO)
  • 31 Mar 2021 Discontinued - Preclinical for Solid tumours in United Kingdom (PO)
  • 31 Mar 2021 Discontinued - Preclinical for Transplant rejection in United Kingdom (PO)

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