PRV 6527

Drug Profile

PRV 6527

Alternative Names: JNJ-244; JNJ-40346527; JNJ-527; PRV-6527

Latest Information Update: 24 Mar 2018

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At a glance

  • Originator Johnson & Johnson Pharmaceutical Research & Development
  • Developer Janssen Research & Development; Provention Bio
  • Class Anti-inflammatories; Antineoplastics; Antirheumatics; Small molecules
  • Mechanism of Action Macrophage colony stimulating factor receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Preclinical Crohn's disease
  • Discontinued Hodgkin's disease; Inflammation; Rheumatoid arthritis

Most Recent Events

  • 21 Jun 2018 Provention Bio plans a Phase-II trial for Acute myeloid Leukemia (second-line therapy or greater) in USA (NCT03557970)
  • 21 Sep 2017 JNJ 4036527 licensed to Provention Bio
  • 21 Sep 2017 Provention Bio plans a phase IIa trial for Crohn's disease in first half of 2018
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