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Basmisanil - Roche

Drug Profile

Basmisanil - Roche

Alternative Names: GABRA5 negative allosteric modulator (NAM) - Roche; RG-1662; RO-5186582

Latest Information Update: 06 Feb 2023

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At a glance

  • Originator Roche
  • Developer Chugai Pharmaceutical; Roche
  • Class Antidementias; Oxazoles; Pyridines; Small molecules; Thiamorpholines
  • Mechanism of Action GABA A alpha 5 receptor modulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Pervasive child development disorders
  • Discontinued Down syndrome; Neurological disorders; Schizophrenia

Most Recent Events

  • 16 Dec 2022 Phase-II clinical trials in Pervasive child development disorders (In children) in Italy, Spain, United Kingdom, Australia (PO) (NCT05307679)
  • 18 Sep 2020 Discontinued - Phase-I for Down syndrome (In volunteers) in Netherlands, United Kingdom (PO)
  • 18 Sep 2020 Discontinued - Phase-I for Down syndrome in Japan (PO)
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