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Evolocumab - Amgen

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Drug Profile

Evolocumab - Amgen

Alternative Names: AMG-145; Repatha

Latest Information Update: 04 Dec 2025

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At a glance

  • Originator Amgen
  • Developer Amgen; Amgen Astellas BioPharma; University Hospital Inselspital
  • Class Anti-ischaemics; Antihyperlipidaemics; Monoclonal antibodies; Vascular disorder therapies
  • Mechanism of Action PCSK9 protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Hypercholesterolaemia
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Coronary disorders; Hypercholesterolaemia; Hyperlipoproteinaemia type IIa; Myocardial infarction; Stroke
  • Phase III Coronary artery disease; Dyslipidaemias; Hyperlipidaemia

Most Recent Events

  • 04 Dec 2025 Evolocumab is still in Registered phase for Hypercholesterolaemia in USA (Amgen website, December 2025)
  • 08 Nov 2025 Updated efficacy and adverse events data from the phase III VESALIUS-CV released by Amgen
  • 03 Oct 2025 Efficacy and adverse events data from a phase III VESALIUS-CV released by Amgen

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