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Research programme: serine/threonine protein kinase inhibitors - Onconova Therapeutics

Drug Profile

Research programme: serine/threonine protein kinase inhibitors - Onconova Therapeutics

Alternative Names: CDK4 inhibitors - Onconova; ON 108110; ON 108600; ON-123300; ON-150030

Latest Information Update: 24 Apr 2018

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At a glance

  • Originator Onconova Therapeutics
  • Developer Icahn School of Medicine at Mount Sinai; Onconova Therapeutics
  • Class Antineoplastics; Pyrimidines; Thiazines
  • Mechanism of Action Casein kinase II inhibitors; Cyclin dependent kinase 9 inhibitors; Cyclin-dependent kinase 4 inhibitors; Cyclin-dependent kinase 6 inhibitors; Fms-like tyrosine kinase 3 inhibitors; Germinal centre kinase inhibitors; NUAK1 protein inhibitors; PIM3 protein inhibitors; Protein tyrosine kinase inhibitors; Protein-serine-threonine kinase inhibitors; Src-Family kinase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Preclinical Acute myeloid leukaemia; Colorectal cancer
  • Research Breast cancer
  • No development reported Cancer

Most Recent Events

  • 15 Jan 2019 Onconova Therapeutics plans a clinical trial in first half of 2019
  • 13 Nov 2018 Onconova Therapeutics plans to file IND for ON 123300 in the first half of 2019
  • 19 Apr 2018 Onconova Therapeutics and HanX Biopharmaceuticals announce intention to submit IND application for ON 123300 in USA and China
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