Alirocumab - Regeneron/Sanofi

Drug Profile

Alirocumab - Regeneron/Sanofi

Alternative Names: ALI; Anti-PCSK9 monoclonal antibody; Anti-proprotein convertase subtilisin kexin type 9 monoclonal antibody; Praluent; REGN-727; SAR-236553

Latest Information Update: 20 Apr 2018

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At a glance

  • Originator Regeneron Pharmaceuticals; sanofi-aventis
  • Developer Regeneron Pharmaceuticals; Sanofi; University Hospital Inselspital
  • Class Antihyperlipidaemics; Monoclonal antibodies
  • Mechanism of Action PCSK9 protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Hyperlipoproteinaemia type IIa
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Hypercholesterolaemia; Hyperlipoproteinaemia type IIa
  • Phase III Coronary artery disease

Most Recent Events

  • 10 Mar 2018 Efficacy and adverse events data from the phase-III ODYSSEY-Outcomes trial in Hyperlipoproteinaemia type IIa and Hypercholesterolaemia presented at the 67th Annual Scientific Session of the American College of Cardiology (ACC-2018)
  • 08 Feb 2018 Regeneron Pharmaceuticals has patent protection for alirocumab in USA and European Union
  • 23 Jan 2018 Sanofi and Regeneron Pharmaceuticals completes the phase-III ODYSSEY Outcomes trial in Hyperlipoproteinaemia type IIa and Hypercholesterolaemia Worldwide (NCT01663402)
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