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Capmatinib - Novartis Oncology

Drug Profile

Capmatinib - Novartis Oncology

Alternative Names: INC-280; INCB-028060; INCB-28060

Latest Information Update: 27 Nov 2019

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At a glance

  • Originator Incyte Corporation
  • Developer Array BioPharma; Novartis Oncology
  • Class Antineoplastics; Benzamides; Heterocyclic bicyclo compounds; Imidazoles; Quinolines; Small molecules; Triazines
  • Mechanism of Action Proto oncogene protein c met inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Non-small cell lung cancer
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Non-small cell lung cancer
  • Phase II Glioblastoma; Liver cancer; Malignant melanoma
  • Phase I/II Colorectal cancer; Head and neck cancer
  • Phase I Breast cancer; Solid tumours
  • No development reported Renal cell carcinoma

Most Recent Events

  • 05 Nov 2019 Novartis Pharmaceuticals plans a phase II trial for Non-small cell lung cancer (First-line therapy, Late-stage disease, Metastatic disease, Combination therapy) in January 2020 (PO) (NCT04139317)
  • 26 Sep 2019 Novartis announces intention to submit regulatory application to the US FDA for Non-small cell lung cancer in the Q4 of 2019
  • 06 Sep 2019 Capmatinib receives Breakthrough Therapy status for Non-small cell lung cancer (Metastatic disease, First-line therapy) in USA
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