Bermekimab - XBiotech

Drug Profile

Bermekimab - XBiotech

Alternative Names: CA-18C3; CV-18C3; Human IGG1 monoclonal antibody specific for human interleukin-1 alpha; Hutruo; MAB-p1; RA-18C3; T2-18C3; Xilonix

Latest Information Update: 01 Nov 2018

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At a glance

  • Originator XBiotech
  • Developer Cedars-Sinai Medical Center; Hellenic Institute for the Study of Sepsis; Ipsen; XBiotech
  • Class Anti-inflammatories; Antihyperglycaemics; Antineoplastics; Antipsoriatics; Antirheumatics; Monoclonal antibodies; Skin disorder therapies; Vascular disorder therapies
  • Mechanism of Action Angiogenesis inhibitors; Immunomodulators; Interleukin 1 alpha inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Preregistration Colorectal cancer
  • Phase III Cachexia
  • Phase II Acne vulgaris; Atopic dermatitis; Hidradenitis suppurativa; Non-small cell lung cancer; Plaque psoriasis; Pyoderma; Type 2 diabetes mellitus; Vascular restenosis
  • No development reported Haematological malignancies

Most Recent Events

  • 26 Oct 2018 XBiotech has patent protection for bermekimab for the treatment of dermatological pathologies and cancer-associated cachexia in Europe in the third quarter of 2018
  • 26 Oct 2018 XBiotech receives patent allowance for bermekimab for the treatment of cardiovascular disease and True HumanTM antibody discovery platform in Australia, Canada, Israel, Mexico, Philippines, Russia and South Korea in the third quarter of 2018
  • 26 Oct 2018 XBiotech plans a clinical trials for Cardiovascular disease
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