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Ipatasertib - Genentech

Drug Profile

Ipatasertib - Genentech

Alternative Names: GCD 0068; GDC-0068; RG-7440; RO 5532961

Latest Information Update: 19 Apr 2024

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At a glance

  • Originator Array BioPharma
  • Developer Big Ten Cancer Research Consortium; Chugai Pharmaceutical; Dana-Farber Cancer Institute; Genentech; National Cancer Institute (USA); Roche; Roche Farma; SOLTI Breast Cancer Research Group
  • Class Amines; Antineoplastics; Chlorinated hydrocarbons; Heterocyclic bicyclo compounds; Ketones; Piperazines; Pyrimidines; Small molecules
  • Mechanism of Action Proto oncogene protein c-akt inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Breast cancer; HER2 negative breast cancer; Triple negative breast cancer
  • Phase II Gastrointestinal cancer; Haematological malignancies; Ovarian cancer; Solid tumours
  • Phase I/II Endometrial cancer; Prostate cancer
  • No development reported HER2 positive breast cancer

Most Recent Events

  • 02 Mar 2024 Hoffmann-La Roche terminates the phase-III IPATunity150 trial in Breast cancer (Combination therapy, Inoperable/Unresectable, Late-stage disease, Metastatic disease, Second-line therapy or greater) in Australia, Brazil, Canada, Japan, Spain, South Korea, UK and USA (PO), based on a strategic sponsor decision and not driven by any safety concerns (NCT04060862)
  • 27 Feb 2024 Genentech completes a phase II trial in Solid tumours (Inoperable/Unresectable, Late-stage disease, Metastatic disease) in USA (PO) (NCT04632992)
  • 28 Dec 2023 No recent reports of development identified for phase-I development in Prostate-cancer(Combination therapy, Hormone refractory) in Georgia (PO)
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