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Ipatasertib - Genentech

Drug Profile

Ipatasertib - Genentech

Alternative Names: GCD 0068; GDC-0068; RG-7440; RO 5532961

Latest Information Update: 19 Sep 2022

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At a glance

  • Originator Array BioPharma
  • Developer Big Ten Cancer Research Consortium; Chugai Pharmaceutical; Dana-Farber Cancer Institute; Genentech; Roche; Roche Farma; SOLTI Breast Cancer Research Group
  • Class Amines; Antineoplastics; Chlorinated hydrocarbons; Heterocyclic bicyclo compounds; Ketones; Piperazines; Pyrimidines; Small molecules
  • Mechanism of Action Proto oncogene protein c-akt inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Breast cancer; Prostate cancer
  • Phase II Gastrointestinal cancer; Ovarian cancer; Solid tumours
  • Phase I/II Endometrial cancer

Most Recent Events

  • 14 Sep 2022 National Cancer Institute plans a phase I/II trial for Endometrial cancer (Recurrent, Metastatic disease, Second-line therapy or greater, Combination therapy) (PO) in January 2023 (NCT05538897)
  • 31 Aug 2022 Genentech completes a phase I/II clinical trials in Prostate cancer (Second-line therapy, Hormone-refractory, Late-stage disease, Metastatic disease) in the USA, France, Italy and Romania, Netherlands, UK, Spain, Czech Republic, Greece (PO) (NCT01485861)
  • 01 Aug 2022 Discontinued - Phase-I/II for Breast cancer (Combination therapy, Late-stage disease, Second-line therapy or greater) in USA, Australia, Italy, South Korea, Spain (PO) (Roche pipeline, August 2022)
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