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Ipatasertib - Genentech

Drug Profile

Ipatasertib - Genentech

Alternative Names: GCD 0068; GDC-0068; RG-7440; RO 5532961

Latest Information Update: 24 May 2023

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At a glance

  • Originator Array BioPharma
  • Developer Big Ten Cancer Research Consortium; Chugai Pharmaceutical; Dana-Farber Cancer Institute; Genentech; Roche; Roche Farma; SOLTI Breast Cancer Research Group
  • Class Amines; Antineoplastics; Chlorinated hydrocarbons; Heterocyclic bicyclo compounds; Ketones; Piperazines; Pyrimidines; Small molecules
  • Mechanism of Action Proto oncogene protein c-akt inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Breast cancer; HER2 negative breast cancer; Triple negative breast cancer
  • Phase II Gastrointestinal cancer; Ovarian cancer; Solid tumours
  • Phase I/II Endometrial cancer; Prostate cancer
  • No development reported HER2 positive breast cancer

Most Recent Events

  • 24 May 2023 Efficacy and adverse events data from a phase I trial in Solid tumours presented at the 114th Annual Meeting of the American Association for Cancer Research - I (AACR-I-2023)
  • 06 Apr 2023 Hoffmann-La Roche completes phase-I trial in Solid tumours (Late-stage disease, Metastatic disease, Second-line therapy or greater) in China (PO) (NCT04341259)
  • 28 Mar 2023 No recent reports of development identified for phase-I development in HER2-positive-breast-cancer(Combination therapy, Inoperable/Unresectable, Late-stage disease, Metastatic disease) in Spain (PO, Tablet)
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