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Zotiraciclib - Adastra Pharmaceuticals/S*Bio

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Drug Profile

Zotiraciclib - Adastra Pharmaceuticals/S*Bio

Alternative Names: SB-1317; TG 02 - S*Bio/Adastra-Pharmaceuticals; TG02; TG02 citrate; Zotiraciclib citrate

Latest Information Update: 04 Jul 2023

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At a glance

  • Originator S*BIO
  • Developer Adastra Pharmaceuticals; European Organisation for Research and Treatment of Cancer; Lee's Pharmaceutical; National Cancer Institute (USA); S*BIO
  • Class Antineoplastics; Heterocyclic compounds with 4 or more rings; Small molecules
  • Mechanism of Action CDC2 protein kinase inhibitors; Cyclin-dependent kinase 2 inhibitors; Cyclin-dependent kinase 5 inhibitors; Cyclin-dependent kinase 9 inhibitors; Extracellular signal-regulated MAP kinase inhibitors; Fms-like tyrosine kinase 3 inhibitors; Janus kinase 2 inhibitors; RNA polymerase II inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Glioma
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I/II Anaplastic astrocytoma; Glioblastoma
  • No development reported Cancer; Chronic lymphocytic leukaemia; Diffuse intrinsic pontine glioma; Leukaemia; Multiple myeloma; Solid tumours

Most Recent Events

  • 02 Jun 2023 Efficacy and adverse events data from the phase Ib STEAM trial for Anaplastic astrocytoma and Glioblastoma presented at the 59th Annual Meeting of the American Society of Clinical Oncology (ASCO-2023)
  • 03 Nov 2022 National Cancer Institute plans a phase I/II trial in Glioma (Recurrent, Second-line therapy or greater) in USA (PO) (NCT05588141)
  • 28 Oct 2022 No recent reports of development identified for phase-I development in Diffuse intrinsic pontine glioma(In adolescents, In children, In infants, In neonates) in Unknown (PO, Capsule)

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