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Futuximab/modotuximab - Symphogen

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Drug Profile

Futuximab/modotuximab - Symphogen

Alternative Names: 992-and-1024; 992/1024; DS 992/DS 1024; DS-1024/DS-992; Modotuximab/futuximab; S-95026; Sym-004

Latest Information Update: 26 May 2026

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At a glance

  • Originator Symphogen
  • Developer Servier; Symphogen
  • Class Antineoplastics; Immunotherapies; Monoclonal antibodies
  • Mechanism of Action ErbB receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Colorectal cancer
  • Phase II Glioma
  • Phase I Solid tumours
  • No development reported Head and neck cancer; Non-small cell lung cancer; Oesophageal cancer

Most Recent Events

  • 05 May 2026 Institut de Recherches Internationales Servier in collaboration with ADIR completes a phase I trial Solid tumours (Late-stage disease, Second-line therapy or greater, Metastatic disease, Inoperable/Unresectable, Combination therapy, Monotherapy) in USA and Canada (IV) (NCT05162755)
  • 28 Jun 2023 Adverse events data from a phase III COLSTAR trial in Colorectal cancer presented at the 25th World Congress on Gastrointestinal Cancer (WCGC-2023)
  • 05 Jul 2022 Phase-III clinical trials in Colorectal cancer (Combination therapy, Metastatic disease, Second-line therapy or greater) in Japan, Poland, Hungary, Belgium (IV) (NCT05223673) (EudraCT2021-003151-41)

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