Drug Profile

Dupilumab - Regeneron/Sanofi

Alternative Names: Dupilumab-Sanofi/Regeneron; Dupixent; REGN-668; SAR-231893

Latest Information Update: 14 Aug 2025

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At a glance

Originator Regeneron Pharmaceuticals; sanofi-aventis
Developer Aimmune Therapeutics; Mayo Clinic; Regeneron Pharmaceuticals; Sanofi; Sanofi-Aventis GmbH
Class Anti-inflammatories; Antiallergics; Antiasthmatics; Antifungals; Antineoplastics; Antipruritics; Immunotherapies; Monoclonal antibodies; Skin disorder therapies
Mechanism of Action Interleukin 13 receptor antagonists; Interleukin 4 receptor antagonists

Orphan Drug Status

Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

Yes - Bullous pemphigoid; Eosinophilic oesophagitis
New Molecular Entity Yes

Marketed Asthma; Atopic dermatitis; Chronic obstructive pulmonary disease; Chronic urticaria; Eosinophilic oesophagitis; Prurigo nodularis; Rhinosinusitis
Registered Bullous pemphigoid
Phase III Pruritus; Wheezing
Phase II/III Eosinophilic gastroenteritis
Phase II Aspergillosis; Eczema; Prostate cancer; Ulcerative colitis; Urticaria
No development reported Allergic asthma
Discontinued Grass pollen hypersensitivity; Peanut hypersensitivity

08 Aug 2025 Regeneron Pharmaceuticals plans a phase III expanded access trial for Eosinophilic-oesophagitis (In Infants, In children) in January 2026 (NCT07112378)
20 Jun 2025 Preregistration for Bullous pemphigoid in Japan (SC) before June 2025
20 Jun 2025 Registered for Bullous pemphigoid (In adults) in USA (SC)

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