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Napabucasin - Boston Biomedical

Drug Profile

Napabucasin - Boston Biomedical

Alternative Names: BB 608; BBI 608 DP1; BBI 608 DP2A; BBI-608; DP1; DP2A; GB-201

Latest Information Update: 19 Nov 2019

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At a glance

  • Originator Boston Biomedical
  • Developer 1Globe Biomedical; Boston Biomedical; Sumitomo Dainippon Pharma
  • Class Antineoplastics; Furans; Naphthoquinones; Small molecules
  • Mechanism of Action Beta catenin inhibitors; Cell death stimulants; STAT3 transcription factor inhibitors; Stem cell inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Gastric cancer; Pancreatic cancer
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Colorectal cancer; Gastric cancer; Non-small cell lung cancer; Oesophageal cancer; Pancreatic cancer
  • Phase I/II Gastrointestinal cancer; Glioblastoma; Liver cancer; Mesothelioma; Solid tumours
  • Phase I Haematological malignancies

Most Recent Events

  • 26 Oct 2019 Pharmacokinetic and adverse events data from a phase I trial in healthy volunteers presented at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics (AACR-NCI-EORTC-2019)
  • 21 Aug 2019 Boston Biomedical completes the phase III BRIGHTER trial in Gastric cancer and Oesophageal cancer (Combination therapy, Late-stage disease, Second-line therapy or greater, Metastatic disease) in Australia, Belgium, Brazil, Bulgaria, Canada, China, Czech Republic, Estonia, France, Germany, Hungary, Israel, Italy, Japan, South Korea, Lithuania, Poland, Romania, Russia, Spain, UK and USA (PO) (NCT02178956) (EudraCT2014-000774-18)
  • 12 Aug 2019 Boston Biomedical completes a phase I/II trial in Cancer (Late-stage disease) in USA and Canada (NCT01775423)
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