APX 005M

Drug Profile

APX 005M

Alternative Names: APX 005; APX 005M; EPI-0050

Latest Information Update: 28 Oct 2018

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At a glance

  • Originator Epitomics
  • Developer Apexigen; Bristol-Myers Squibb; Parker Institute for Cancer Immunotherapy; University of California at San Francisco; University of Texas M. D. Anderson Cancer Center; Yale University
  • Class Antineoplastics; Immunotherapies; Monoclonal antibodies
  • Mechanism of Action Apoptosis stimulants; CD40 antigen stimulants; Immunomodulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Gastric cancer; Oesophageal cancer
  • Phase I/II Malignant melanoma; Non-small cell lung cancer; Pancreatic cancer
  • Phase I Brain cancer; Glioma; Renal cell carcinoma
  • No development reported Solid tumours

Most Recent Events

  • 28 Oct 2018 No recent reports of development identified for phase-I development in Solid-tumours in USA (Parenteral)
  • 25 Oct 2018 Apexigen and Columbia University plans a phase II trial for Soft tissue sarcoma (Unresectable, Late-stage disease, Metastatic disease, Treatment naïve, Combination therapy) in December 2018 (IV) (NCT03719430)
  • 08 Oct 2018 Apexigen and Neon Therapeutics initiates a phase Ib NT-003 trial in Malignant melanoma (Combination therapy, Late-stage disease, Metastatic disease) in USA (IV) (NCT03597282)
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