Drug Profile


Alternative Names: Captisol® enabled prexasertib; LY 2606368; LY2606368 MsOH H2O

Latest Information Update: 01 Jun 2018

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At a glance

  • Originator Array BioPharma; Eli Lilly
  • Developer Dana-Farber Cancer Institute; Eli Lilly; National Cancer Institute (USA)
  • Class Antineoplastics; Nitriles; Pyrazines; Pyrazoles; Small molecules
  • Mechanism of Action Checkpoint kinase 1 inhibitors; Checkpoint kinase 2 inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Breast cancer; Fallopian tube cancer; Ovarian cancer; Peritoneal cancer; Small cell lung cancer; Solid tumours
  • Phase I Acute myeloid leukaemia; Colorectal cancer; Head and neck cancer; Myelodysplastic syndromes; Non-small cell lung cancer

Most Recent Events

  • 16 May 2018 Phase-I clinical trials in Solid tumours (Combination therapy, Late-stage disease, Inoperable/Unresectable, Metastatic disease) in USA (IV) (NCT03495323)
  • 12 Apr 2018 Eli Lilly in collaboration with Dana-Farber Cancer Institute plans I trial for Solid tumours (Late-stage disease) in USA (NCT03495323)
  • 09 Apr 2018 Phase-II clinical trials in Fallopian tube cancer (Second-line therapy or greater) in United Kingdom, Spain, South Korea, Italy, Israel, Belgium, Australia, USA (IV) (NCT03414047) (EudraCT2017-004009-42)
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