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CSL 112

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Drug Profile

CSL 112

Alternative Names: ApoA-1; Apolipoprotein A-I - CSL Behring; CSL-112; CSL112 (reconstituted HDL) - CSL; CSL112 apo-AI; rHDL - CSL

Latest Information Update: 13 Feb 2024

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At a glance

  • Originator CSL
  • Class Anti-ischaemics; Lipoproteins; Recombinant proteins; Vascular disorder therapies
  • Mechanism of Action Apolipoprotein A-I replacements
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Myocardial infarction
  • Discontinued Atherosclerosis

Most Recent Events

  • 11 Feb 2024 Efficacy and adverse events data from a phase III AEGIS trial in Myocardial infarction released by CSL
  • 25 Aug 2023 Efficacy data from phase II trial in Myocardial infarction presented at the ESC Congress 2023 - Annual Congress of the European Society of Cardiology (ESC-Card-2023)
  • 16 Feb 2023 CSL completes a phase III trial in Myocardial infarction in Argentina, Belgium, Brazil, Chile, Colombia, Croatia, Estonia, Finland, Greece, Hong Kong, South Korea, Latvia, Lithuania, Malaysia, Mexico, New Zealand, Norway, Portugal, Romania, Russia, Serbia, Singapore, Slovakia, South Africa, Sweden, Switzerland, Taiwan, Thailand, Turkey, Ukraine, United Kingdom, Spain, Poland, Netherlands, Italy, Israel, Hungary, Germany, France, Denmark, Czech Republic, Canada, Bulgaria, Austria, Australia, Japan, Georgia and Peru (IV) (NCT03473223; EudraCT-2017-000996-98)

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