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Netupitant/palonosetron - Helsinn

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Drug Profile

Netupitant/palonosetron - Helsinn

Alternative Names: AKYNZEO; Akynzeo; Fosnetupitant/palonosetron; NEPA - Helsinn; NEPA-IV; Palonosetron/Fosnetupitant; Palonosetron/netupitant

Latest Information Update: 23 Feb 2026

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At a glance

  • Originator Helsinn
  • Developer CSL Vifor; Glenmark Pharmaceuticals Ltd; Helsinn; HK inno.N; Mundipharma International; Purdue Pharma; Taiho Pharmaceutical
  • Class Antiemetics; Isoquinolines; Pyridines; Quinuclidines; Small molecules
  • Mechanism of Action Neurokinin 1 antagonists; Serotonin 3 receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity No

Highest Development Phases

  • Marketed Chemotherapy-induced nausea and vomiting

Most Recent Events

  • 18 Feb 2026 Helsinn plans to launch fosnetupitant/palonosetron for Chemotherapy induced nausea and vomiting (Prevention) in the European Union, Iceland, Liechtenstein, Norway (PO, Suspension) in 2026
  • 12 Feb 2026 Registered for Chemotherapy-induced nausea and vomiting (Prevention) in Iceland, Liechtenstein, Norway, European Union (PO)
  • 11 Feb 2026 Netupitant/palonosetron licensed to MagnaPharm in Poland, Romania, Czech Republic, Slovakia and Hungary

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