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Aticaprant - Johnson & Johnson Innovative Medicine

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Drug Profile

Aticaprant - Johnson & Johnson Innovative Medicine

Alternative Names: AVTX-501; CERC 501; JNJ-3964; JNJ-67953964; JNJ-67953964-AAA; LY-2456302

Latest Information Update: 29 Aug 2025

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At a glance

  • Originator Eli Lilly and Company
  • Developer Avalo Therapeutics; Eli Lilly and Company; Johnson & Johnson Innovative Medicine
  • Class Antidepressants; Benzamides; Benzene derivatives; Drug withdrawal therapies; Fluorinated hydrocarbons; Pyrrolidines; Small molecules; Smoking cessation therapies
  • Mechanism of Action Opioid kappa receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued Alcoholism; Cocaine-related disorders; Major depressive disorder; Smoking withdrawal

Most Recent Events

  • 30 May 2025 Janssen Research & Development terminates a phase III VENTURA-7 trial for Major depressive disorder (Adjunctive treatment) in USA (PO, Tablet), due to sponsor decision (NCT06514742)
  • 25 Apr 2025 Janssen Research & Development terminates a phase III VENTURA-5 trial for Major depressive disorder (Adjunctive treatment) in USA, Argentina, Belgium, Brazil, Bulgaria, France, Germany, Greece, Mexico, Poland, Romania, Spain and Turkey (PO, Tablet) due tosponsor decision (NCT06635135) (EudraCT 2024-511057-22-00)
  • 06 Mar 2025 Discontinued - Phase-I for Major depressive disorder (In volunteers) in Belgium (PO)

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