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Prexigebersen - Bio-Path Holdings

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Drug Profile

Prexigebersen - Bio-Path Holdings

Alternative Names: BP 100-1-01; BP-100-1.01; BP-1001; BP1001-A; L-Grb-2; L-Grb-2 antisense; Liposomal Grb2 antisense oligonucleotide; Prexigebersen-A

Latest Information Update: 12 May 2025

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At a glance

  • Originator University of Texas M. D. Anderson Cancer Center
  • Developer Bio-Path Holdings; University of Texas M. D. Anderson Cancer Center
  • Class Antineoplastics; Antisense oligonucleotides; Obesity therapies
  • Mechanism of Action Gene silencing; GRB2 adaptor protein expression inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Chronic myeloid leukaemia; Acute myeloid leukaemia
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Acute myeloid leukaemia; Myelodysplastic syndromes
  • Phase I/II Chronic myeloid leukaemia
  • Phase I Solid tumours
  • Preclinical Obesity
  • No development reported Breast cancer; Colorectal cancer; Head and neck cancer; Lymphoma; Precursor cell lymphoblastic leukaemia-lymphoma; Thyroid cancer

Most Recent Events

  • 01 May 2025 Pharmacodynamics data from a preclinical study in Obesity released by Bio-Path Holdings
  • 28 Mar 2025 Bio-Path Holdings has patent protection for Prexigebersen in New Zealand
  • 28 Mar 2025 Bio-Path Holdings receives 'Notice of Allowance' for Prexigebersen in USA

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