Prexigebersen - Bio-Path Holdings

Drug Profile

Prexigebersen - Bio-Path Holdings

Alternative Names: BP 100-1-01; BP-100-1.01; BP-1001; L-Grb-2; L-Grb-2 antisense; Liposomal Grb2 antisense oligonucleotide

Latest Information Update: 03 Sep 2018

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At a glance

  • Originator University of Texas M. D. Anderson Cancer Center
  • Developer Bio-Path Holdings; University of Texas M. D. Anderson Cancer Center
  • Class Antineoplastics; Antisense oligonucleotides; Nucleotides
  • Mechanism of Action GRB2 adaptor protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Chronic myeloid leukaemia; Acute myeloid leukaemia
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Acute myeloid leukaemia
  • Phase I/II Chronic myeloid leukaemia
  • Preclinical Colorectal cancer; Head and neck cancer; Lymphoma; Solid tumours; Thyroid cancer
  • No development reported Breast cancer; Myelodysplastic syndromes; Precursor cell lymphoblastic leukaemia-lymphoma

Most Recent Events

  • 03 Sep 2018 Prexigebersen is still undergoing preclinical development for Solid-tumours in USA
  • 24 Jun 2018 Biomarkers information updated
  • 28 Apr 2018 No recent reports of development identified for phase-I development in Chronic-myeloid-leukaemia in USA (IV, Injection)
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