BL 8040

Drug Profile

BL 8040

Alternative Names: 4F-Benzoyl-TN14003; BKT-140; BL-8040; TF-14016; TN-14003

Latest Information Update: 24 Aug 2018

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At a glance

  • Originator Kyoto University
  • Developer Biokine Therapeutics; BioLineRx; Genentech; Merck AG; University of Texas M. D. Anderson Cancer Center
  • Class Antianaemics; Antineoplastics; Cyclic peptides; Peptides
  • Mechanism of Action CXCR4 receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Acute myeloid leukaemia; Stem cell mobilisation
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase III Stem cell mobilisation
  • Phase II Acute myeloid leukaemia; Pancreatic cancer
  • Phase I/II Aplastic anaemia; Gastric cancer; Multiple myeloma; Myelodysplastic syndromes; Non-small cell lung cancer
  • No development reported Autoimmune disorders; Chronic myeloid leukaemia; Thrombocytopenia

Most Recent Events

  • 14 Aug 2018 Data Monitoring Committee recommends early continuation to randomised placebo-controlled part of the phase III GENESIS trial for the mobilisation of haematopoietic stem cells (HSCs) used for autologous transplantation in Multiple myeloma
  • 07 Aug 2018 Efficacy data from the lead-in period of the phase III GENESIS trial in stem-cell mobilization released by BioLineRx
  • 30 Jul 2018 BioLineRx submits regulatory application to initiate/include triple combination arm in the KEYNOTE-202 trial in Pancreatic cancer
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