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Taladegib - Endeavor BioMedicines

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Drug Profile

Taladegib - Endeavor BioMedicines

Alternative Names: ENV 101; ENV-IPF-101; ENV-ONC-101; LY-2940680

Latest Information Update: 18 Jul 2025

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At a glance

  • Originator Eli Lilly and Company
  • Developer Eli Lilly and Company; Endeavor BioMedicines; Ignyta
  • Class Antifibrotics; Antineoplastics; Benzamides; Fluorobenzenes; Phthalazines; Piperidines; Pyrazoles; Small molecules
  • Mechanism of Action SMO protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Idiopathic pulmonary fibrosis
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Cancer; Idiopathic pulmonary fibrosis; Solid tumours
  • Discontinued Adenocarcinoma; Basal cell cancer; Ovarian cancer; Small cell lung cancer

Most Recent Events

  • 16 Jul 2025 Taladegib - Endeavor BioMedicines receives Orphan Drug status for Idiopathic pulmonary fibrosis in European Union
  • 16 Jul 2025 Taladegib - Endeavor BioMedicines receives Orphan Drug status for Idiopathic pulmonary fibrosis in USA
  • 15 Nov 2024 Endeavor Biomedicines initiates enrolment in phase-II WHISTLE-PF trial for Idiopathic pulmonary fibrosis ( in Australia (PO) (NCT06422884)

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