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Unesbulin - PTC Therapeutics

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Drug Profile

Unesbulin - PTC Therapeutics

Alternative Names: PTC-596

Latest Information Update: 26 Apr 2024

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At a glance

  • Originator PTC Therapeutics
  • Developer PTC Therapeutics; University of Oklahoma
  • Class Amines; Antineoplastics; Benzimidazoles; Fluorinated hydrocarbons; Pyrimidines; Small molecules
  • Mechanism of Action BMI1 protein inhibitors; Tubulin polymerisation inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Diffuse intrinsic pontine glioma; Leiomyosarcoma
  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued Diffuse intrinsic pontine glioma; Fallopian tube cancer; Glioblastoma; Leiomyosarcoma; Ovarian cancer; Peritoneal cancer; Solid tumours

Most Recent Events

  • 31 Mar 2024 PTC Therapeutics completes the Phase-I clinical trials in Ovarian cancer, Peritoneal cancer, Fallopian tube cancer (Combination therapy, First-line therapy, Late-stage disease, Metastatic disease, Neoadjuvant therapy) in USA (PO) (NCT03206645)
  • 28 Feb 2024 No recent reports of development identified for phase-I development in Diffuse intrinsic pontine glioma(In adolescents, In children, First-line therapy, In adults) in USA (PO, Capsule)
  • 28 Feb 2024 No recent reports of development identified for phase-I development in Glioblastoma(In adolescents, In children, First-line therapy, In adults) in USA (PO, Capsule)

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