Drug Profile


Alternative Names: G154578; GLPG-0778; GSK-2586184; GSK2586184A

Latest Information Update: 24 Mar 2018

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At a glance

  • Originator Galapagos NV
  • Developer GlaxoSmithKline
  • Class Amides; Azetidines; Cyclopropanes; Pyridines; Small molecules; Triazoles
  • Mechanism of Action Immunosuppressants; Janus kinase 1 inhibitors; Signal transduction pathway inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase Unknown Unspecified
  • Discontinued Plaque psoriasis; Systemic lupus erythematosus; Ulcerative colitis

Most Recent Events

  • 15 Dec 2016 Biomarkers information updated
  • 06 Nov 2014 Efficacy and adverse events data from a phase IIa trial in Plaque psoriasis released by Galapagos
  • 26 Aug 2014 Discontinued - Phase-I for Ulcerative colitis in Netherlands (PO)
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