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Talazoparib - Pfizer

Drug Profile

Talazoparib - Pfizer

Alternative Names: BMN-673; BMN-673ts; LT 006673; LT-00673; LT-673; MDV-3800; Talazoparib tosylate; TALZENNA

Latest Information Update: 02 Apr 2024

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At a glance

  • Originator LEAD Therapeutics
  • Developer Astellas Pharma; Big Ten Cancer Research Consortium; BioGene Pharmaceutical; Brown University; Calithera Biosciences; Center Trials & Treatment; Dana-Farber Cancer Institute; Epizyme; LifeSpan; National Cancer Institute (USA); Peter MacCallum Cancer Centre; Pfizer; St. Jude Childrens Research Hospital; Stanford University; Translational Research In Oncology; University of California at San Francisco; University of Maryland Greenbaum Cancer Center; University of Texas M. D. Anderson Cancer Center; Zenith Epigenetics
  • Class Antineoplastics; Fluorobenzenes; Phthalazines; Pyridines; Small molecules; Triazoles
  • Mechanism of Action Poly(ADP-ribose) polymerase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Breast cancer; HER2 negative breast cancer; Prostate cancer
  • Phase III Ovarian cancer
  • Phase II Endometrial cancer; Fallopian tube cancer; Peritoneal cancer; Small cell lung cancer; Solid tumours; Squamous cell cancer; Triple negative breast cancer
  • Phase I/II Acute myeloid leukaemia
  • No development reported Haematological malignancies; Myelodysplastic syndromes

Most Recent Events

  • 02 Apr 2024 Pfizer completes a phase-I clinical trial in Breast cancer (Metastatic disease, Recurrent, Second-line therapy or greater, Combination therapy) in USA (PO) (NCT04134884)
  • 07 Mar 2024 Zenith Epigenetics in collaboration with Pfizer and Newsoara Biopharma terminates a phase II trial in Triple-negative-breast-cancer (Combination therapy, Late-stage disease, Metastatic disease, Recurrent, Second-line therapy or greater) in China (PO), due to the results from an interim futility analysis (NCT03901469) (EudraCT2018-003906-26)
  • 25 Jan 2024 Efficacy data from the phase-III TALAPRO-2 trial in Prostate cancer presented at the ASCO Genitourinary Cancers Symposium (ASCO-GCS-2024)
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