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Ozanimod - Celgene Corporation

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Drug Profile

Ozanimod - Celgene Corporation

Alternative Names: BMS-986374; Ozanimod-HCl; Ozanimod-hydrochloride; RPC-1063; RPC-1063-HCl; ZEPOSIA

Latest Information Update: 16 Jun 2026

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At a glance

  • Originator The Scripps Research Institute
  • Developer Bristol-Myers Squibb; Celgene Corporation; Receptos
  • Class Amines; Anti-inflammatories; Benzene derivatives; Indenes; Nitriles; Oxadiazoles; Small molecules
  • Mechanism of Action Sphingosine 1 phosphate receptor modulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Ulcerative colitis
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Multiple sclerosis; Ulcerative colitis
  • Phase III Crohn's disease

Most Recent Events

  • 07 Feb 2026 Efficacy adverse events and pharmacodynamics data from a phase III ENLIGHTEN trial in Multiple sclerosis presented at Americas Committee for Treatment and Research in Multiple Sclerosis Forum, 2026 (ACTRIMS-2026)
  • 30 Sep 2025 Celgene completes phase-II/III clinical trials in Ulcerative colitis in Japan (PO) (NCT03915769)
  • 24 Sep 2025 Updated efficacy data from the phase III ENLIGHTEN trial in Multiple sclerosis presented at the 41st Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS-2025)

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