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Ozanimod - Celgene Corporation

Drug Profile

Ozanimod - Celgene Corporation

Alternative Names: BMS-986374; Ozanimod-HCl; Ozanimod-hydrochloride; RPC-1063; RPC-1063-HCl; ZEPOSIA

Latest Information Update: 29 Oct 2025

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At a glance

  • Originator The Scripps Research Institute
  • Developer Bristol-Myers Squibb; Celgene Corporation; Receptos
  • Class Amines; Anti-inflammatories; Benzene derivatives; Indenes; Nitriles; Oxadiazoles; Small molecules
  • Mechanism of Action Sphingosine 1 phosphate receptor modulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Ulcerative colitis
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Multiple sclerosis; Ulcerative colitis
  • Phase III Crohn's disease

Most Recent Events

  • 30 Sep 2025 Celgene completes phase-II/III clinical trials in Ulcerative colitis in Japan (PO) (NCT03915769)
  • 24 Sep 2025 Updated efficacy data from the phase III ENLIGHTEN trial in Multiple sclerosis presented at the 41st Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS-2025)
  • 15 May 2025 Celgene terminates phase III trial in Multiple sclerosis (Treatment-experienced) in Canada, Puerto Rico, USA due to change business objective (PO) (NCT04140305)

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