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Ozanimod - Celgene Corporation

Drug Profile

Ozanimod - Celgene Corporation

Alternative Names: BMS-986374; Ozanimod-HCl; Ozanimod-hydrochloride; RPC-1063; RPC-1063-HCl; ZEPOSIA

Latest Information Update: 29 Jun 2025

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At a glance

  • Originator The Scripps Research Institute
  • Developer Bristol-Myers Squibb; Celgene Corporation; Receptos
  • Class Amines; Anti-inflammatories; Benzene derivatives; Indenes; Nitriles; Oxadiazoles; Small molecules
  • Mechanism of Action Sphingosine 1 phosphate receptor modulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Ulcerative colitis
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Multiple sclerosis; Ulcerative colitis
  • Phase III Crohn's disease

Most Recent Events

  • 15 May 2025 Celgene terminates phase III trial in Multiple sclerosis (Treatment-experienced) in Canada, Puerto Rico, USA due to change business objective (PO) (NCT04140305)
  • 08 Apr 2025 Phase-III clinical trials in Multiple sclerosis (Treatment-experienced, In children, In adolescents) in Italy, Mexico, Poland, Portugal, USA, Romania, Spain, Turkey, Taiwan (PO) (NCT06408259)
  • 07 Mar 2025 Bristol-Myers Squibb terminates phase III trial in Ulcerative colitis in Taiwan and China (PO) (NCT05644665) due to change in business objectives (NCT05644665)

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