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Merestinib - Eli Lilly and Company

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Drug Profile

Merestinib - Eli Lilly and Company

Alternative Names: LY-2801653

Latest Information Update: 05 Nov 2023

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At a glance

  • Originator Eli Lilly and Company
  • Developer Dana-Farber Cancer Institute; Eli Lilly and Company; Indiana University School of Medicine; Roswell Park Cancer Institute; University of Utah
  • Class Amides; Antineoplastics; Dihydropyridines; Fluorobenzenes; Indazoles; Pyrazoles; Small molecules
  • Mechanism of Action Axl receptor tyrosine kinase inhibitors; Discoidin domain receptor 1 antagonists; Discoidin domain receptor 2 antagonists; MKNK1 protein inhibitors; MKNK2 protein inhibitors; Proto-oncogene protein c-met inhibitors; RON protein inhibitors; ROS1 protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Biliary cancer; Non-small cell lung cancer; Solid tumours
  • Preclinical Adenocarcinoma
  • No development reported Acute myeloid leukaemia; Bone metastases; Cancer

Most Recent Events

  • 01 Oct 2023 Dana-Farber Cancer Institute and Eli Lilly and Company terminates phase II trial in Solid tumours and Non-small cell lung cancer (Metastatic disease, Second-line therapy or greater) in USA due to funding limitation (PO) (NCT02920996)
  • 28 May 2022 No recent reports of development identified for phase-I development in Acute-myeloid-leukaemia(Combination therapy, Second-line therapy or greater) in USA (PO)
  • 28 May 2022 No recent reports of development identified for phase-I development in Bone metastases in USA (PO)

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