Afuresertib - Novartis Oncology

Drug Profile

Afuresertib - Novartis Oncology

Alternative Names: 2110183; Afuresertib hydrochloride; ASB-183; GSK-2110183; GSK2110183B; GSK2110183C

Latest Information Update: 09 Apr 2018

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At a glance

  • Originator GlaxoSmithKline
  • Developer GlaxoSmithKline; Novartis Oncology; University Health Network
  • Class Amides; Antineoplastics; Fluorobenzenes; Pyrazoles; Small molecules; Thiophenes
  • Mechanism of Action Proto oncogene protein c-akt inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued Cancer; Chronic lymphocytic leukaemia; Gastric cancer; Haematological malignancies; Histiocytosis; Multiple myeloma; Ovarian cancer; Solid tumours

Most Recent Events

  • 30 Jun 2017 University Health Network, Toronto and Novartis completes a phase II trial in Chronic lymphocytic leukaemia (combination therapy, Second-line therapy or greater) in Canada (PO) (NCT01532700)
  • 27 Jan 2017 Discontinued - Phase-I for Cancer (In volunteers) in Australia, Australia (PO) (Novartis 20-F filed in 2017)
  • 27 Jan 2017 Discontinued - Phase-I for Gastric cancer (Combination therapy, Late-stage disease, Second-line therapy or greater) in South Korea, Taiwan (PO) (Novartis 20-F filed in 2017)
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