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Murepavadin - Spexis

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Drug Profile

Murepavadin - Spexis

Alternative Names: POL 7080; POL 7080 acetate; RG 7929; RO 7033877

Latest Information Update: 28 Mar 2025

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At a glance

  • Originator Polyphor; University of Zurich
  • Developer Polyphor; Spexis
  • Class Antibacterials; Cyclic peptides; Epitopes; Macrocyclic compounds; Peptidomimetics
  • Mechanism of Action Imp protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • No development reported Pseudomonal infections
  • Discontinued Gram-negative infections; Nosocomial infections; Ventilator associated pneumonia

Most Recent Events

  • 28 Mar 2025 No recent reports of development identified for phase-I development in Pseudomonal-infections in Switzerland (Intranasal, Inhalant)
  • 30 May 2023 Spexis plans a phase Ib/II trial for Cystic fibrosis and Non-cystic fibrosis bronchiectasis in 2023
  • 10 Jan 2023 Spexis completes a phase I trial for Pseudomonal infections (In volunteers) (Inhalent)

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