Drug Profile

Blarcamesine - Anavex Life Sciences

Alternative Names: AE-37 hydrochloride; ANA001-HCl; ANAVEX 2-73; Blarcamesine hydrochloride - Anavex Life Sciences

Latest Information Update: 22 Oct 2026

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At a glance

Originator Anavex Life Sciences
Developer Anavex Life Sciences; The Michael J. Fox Foundation for Parkinsons Research
Class Antidementias; Antidepressants; Antiepileptic drugs; Antiparkinsonians; Anxiolytics; Behavioural disorder therapies; Biphenyl compounds; Dimethylamines; Furans; Neuroprotectants; Nootropics; Small molecules; Vascular disorder therapies
Mechanism of Action Muscarinic receptor modulators; Sigma-1 receptor agonists

Orphan Drug Status

Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

Yes - Fragile X syndrome; Rett syndrome; Infantile spasms
New Molecular Entity Yes

Phase III Rett syndrome
Phase II/III Alzheimer's disease; Fragile X syndrome; Unspecified
Phase II Parkinson's disease
Phase I Angelman syndrome
No development reported Infantile spasms
Discontinued Amyotrophic lateral sclerosis; Anxiety disorders; Autistic disorder; Cognition disorders; Multiple sclerosis; Stroke

15 Oct 2026 Anavex receives IND clearance for Blarcamesine in Fragile X Syndrome in US
15 Oct 2026 Anavex plans phase IIa trial Fragile X Syndrome in US (PO)
25 Aug 2026 Anavex Life Sciences submits a formal meeting request to the US FDA to discuss adding pediatric patients to the approved phase III ANAVEX2-73-RS-005 protocol in Rett syndrome

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