Drug Profile


Alternative Names: ANAVEX-2-73

Latest Information Update: 13 Aug 2018

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At a glance

  • Originator Anavex Life Sciences
  • Developer ABX-CRO; Anavex Life Sciences; The Michael J. Fox Foundation for Parkinsons Research
  • Class Antidementias; Dimethylamines; Furans; Neuroprotectants; Small molecules
  • Mechanism of Action Calcium channel antagonists; Muscarinic M1 receptor agonists; Muscarinic M2 receptor antagonists; Muscarinic M3 receptor antagonists; NMDA receptor antagonists; Sigma-1 receptor agonists; Sodium channel antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Epilepsy; Rett syndrome
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Alzheimer's disease; Parkinson's disease
  • Phase I Cognition disorders; Epilepsy; Rett syndrome
  • Preclinical Angelman syndrome; Anxiety disorders; Autistic disorder; Fragile X syndrome; Multiple sclerosis
  • No development reported Amyotrophic lateral sclerosis; Stroke

Most Recent Events

  • 09 Jul 2018 Spanish Agency for Medicinal Products and Medical Devices (AEMPS) approves clinical trial application for phase II trial of ANAVEX 2-73 in Parkinson’s Disease (PDD) Dementia
  • 04 Jul 2018 Phase-II clinical trials in Parkinson's disease in Spain (PO) (EudraCT2017-004335-36)
  • 03 Jul 2018 Australian Human Research Ethics Committee grants approval to initiate phase IIb/III trial in Alzheimer's disease
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