Drug Profile

Blarcamesine - Anavex Life Sciences

Alternative Names: AE-37 hydrochloride; ANA001-HCl; ANAVEX 2-73; Blarcamesine hydrochloride - Anavex Life Sciences

Latest Information Update: 17 Apr 2025

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At a glance

Originator Anavex Life Sciences
Developer Anavex Life Sciences; The Michael J. Fox Foundation for Parkinsons Research
Class Antidementias; Antidepressants; Antiepileptic drugs; Antiparkinsonians; Anxiolytics; Behavioural disorder therapies; Biphenyl compounds; Dimethylamines; Furans; Neuroprotectants; Nootropics; Small molecules
Mechanism of Action Muscarinic receptor modulators; Sigma-1 receptor agonists

Orphan Drug Status

Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

Yes - Fragile X syndrome; Rett syndrome; Infantile spasms
New Molecular Entity Yes

Preregistration Alzheimer's disease
Phase III Rett syndrome
Phase II/III Fragile X syndrome; Unspecified
Phase II Parkinson's disease
Phase I Angelman syndrome
No development reported Infantile spasms
Discontinued Amyotrophic lateral sclerosis; Anxiety disorders; Autistic disorder; Cognition disorders; Multiple sclerosis; Stroke

05 Apr 2025 Updated efficacy data from the phase IIb/III ATTENTION-AD trial for Alzheimer’s disease released by Anavex Life Sciences
05 Apr 2025 Anavex Life Sciences plans phase III trial for Alzheimer's disease
27 Jan 2025 Anavex Life Sciences has patent protection for Blarcamesine in Neurologic indications in USA

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