Melphalan flufenamide - Oncopeptides

Drug Profile

Melphalan flufenamide - Oncopeptides

Alternative Names: J-1; Mel-flufen

Latest Information Update: 18 Jul 2018

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At a glance

  • Originator Oncopeptides
  • Class Amides; Amino acids; Antineoplastics; Fluorobenzenes
  • Mechanism of Action Alkylating agents; Caspase 3 stimulants; DNA synthesis inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Multiple myeloma
  • New Molecular Entity No
  • Available For Licensing Yes

Highest Development Phases

  • Phase III Multiple myeloma
  • Discontinued Bladder cancer; Non-small cell lung cancer; Ovarian cancer

Most Recent Events

  • 14 Jun 2018 Updated safety and efficacy data from the phase II HORIZON trial in Multiple myeloma presented at the 23rd Congress of the European Haematology Association (EHA-2018)
  • 16 Apr 2018 Oncopeptides AB initiates enrolment in a phase I/II trial for Multiple myeloma (Combination therapy, Second-line therapy or greater) in USA and Spain (IV) (NCT03481556)
  • 14 Dec 2017 Adverse events and efficacy data from a phase I/II trial in Multiple myeloma presented at the 59th Annual Meeting and Exposition of the American Society of Hematology (ASH-Hem-2017)
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