Utomilumab - Pfizer

Drug Profile

Utomilumab - Pfizer

Alternative Names: 4-1BB agonist monoclonal antibody- Pfizer; PF-05082566; PF-2566; PF-5082566

Latest Information Update: 20 Apr 2018

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At a glance

  • Originator Pfizer
  • Developer M. D. Anderson Cancer Center; National Cancer Institute (USA); Pfizer; Stanford University School of Medicine
  • Class Antineoplastics; Monoclonal antibodies
  • Mechanism of Action CD137 antigen agonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Oropharyngeal cancer; Solid tumours
  • Phase I Breast cancer; Colorectal cancer
  • No development reported B cell lymphoma; Non-Hodgkin's lymphoma

Most Recent Events

  • 04 Apr 2018 Phase-II clinical trials in Oropharyngeal cancer (Combination therapy, Second-line therapy or greater, First line therapy) in USA (IV) (NCT03258008)
  • 30 Jan 2018 Pfizer plans the phase II AVIATOR trial for Breast Cancer in the US , (NCT03414658)
  • 18 Jan 2018 Kite Pharma and Pfizer agree to co-develop utomilumab, in combination with axicabtagene ciloleucel, for B-cell lymphoma
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